Epoetin beta

Adult: Dosage is individualised and based on the required amount of pre-donated blood and the endogenous red cell reserve. Usual dosing range: 200-800 international units/kg via IV inj over approx 2 minutes twice weekly (Max: 1,600 international units/kg/week). Alternatively, 150-600 international units/kg via SC inj twice weekly (Max: 1,200 international units/kg/week). Treatment should be given over 4 weeks. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).

Adult: Dosage is individualised and adjusted according to target Hb concentration. Correction phase: IV administration (preferred route for patients undergoing haemodialysis): Initially, 40 international units/kg 3 times weekly for 4 weeks; then may increase the dose to 80 international units/kg 3 times weekly based on Hb response. May further increase the dose in increments of 20 international units/kg 3 times weekly at monthly intervals if needed. Max: 720 international units/kg/week. Doses are given via IV inj over approx 2 minutes; may inject via the arteriovenous fistula at the end of dialysis. SC administration (preferred route for patients not on haemodialysis): Initially, 60 international units/kg/week given as a single dose or in 3-7 divided doses. May increase the dose every 4 weeks by 60 international units/kg/week if needed. Max: 720 international units/kg/week. Doses are given via SC inj. Maintenance phase: After reaching the target Hb level, initially reduce to half of the previously administered dose then adjust the dose at intervals of 1-2 weeks according to response. The weekly SC dose may be given as 1 inj per week or in divided doses of 3 times/week or 7 times/week; those who become stable on a once weekly regimen may be switched to once every 2 weeks (dose increase may be necessary). Use the lowest necessary dose to control symptoms of anaemia. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Same as adult dose.

Child: As prevention: Infants gestational age <34 weeks birth weight of 750-1,500 g: 250 international units/kg 3 times weekly for 6 weeks. Initiate treatment as early as possible (preferably within 3 days of birth). Treatment recommendations may vary among individual products and between countries (refer to specific product guidelines).
Neonate: As prevention: Gestational age <34 weeks birth weight of 750-1,500 g: 250 international units/kg 3 times weekly for 6 weeks. Initiate treatment as early as possible (preferably within 3 days of birth). Treatment recommendations may vary among individual products and between countries (refer to specific product guidelines).

Adult: Dosage is individualised and adjusted according to target Hb concentration. Initially, 30,000 international units (approx 450 international units/kg) weekly, given as a single dose or in 3-7 divided doses. After 4 weeks, the dose may be doubled if needed. Discontinue treatment if no adequate response is achieved after 4 weeks at the higher dose. Max: 60,000 international units/week. Maintenance: After reaching the target Hb level, may reduce the dose by 25-50% to maintain the desired Hb level; consider appropriate dose titration. Continue treatment up to 4 weeks after the completion of chemotherapy. Use the lowest necessary dose to control symptoms of anaemia. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).